There are some evidences that temporary hearing loss is induced by disturbance of cochlear microcirculation due to the inhibition of prostaglandin synthesis by salicylate, however, the mechanism of salicylate ototoxicity has been still under
study.
We previously suggested that the increase of unknown compound concentration in perilymph of guinea pig might be important for the mechanism of salicylate ototoxicity. So we tried to compare the time course of unknown compound concentration to
salicylate
concentration in perilymph. Sodium salicylate(460mg/kg) was injected intraperitoneally to guinea pig. Unknown compound concentratin in perilymph was measured before the injection ad 1 hour, 3 hours, 5 hours, 7 hours and 24 hours after injection,
using
HPLC-ECD. The time course of unknown compound concentration reveals maximum level at 5 hours and nearly control level at 24 hours, and this is similar to the change of salicylate concentration in perilymph. These data might be another evidence to
our
understanding of unknown compoud-related salicylate ototoxicity.
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